News

C&EN6d
Evaluating the Promiscuous Nature of Tyrosine Kinase Inhibitors Assessed in A431 Epidermoid Carcinoma Cells by Both Chemical- and Phosphoproteomics
Find more information on the Altmetric Attention Score and how the score is calculated. Deregulation of protein tyrosine kinase signaling has been linked to many diseases, most notably cancer. As a ...
ahajournals.org17d
Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
The angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are postulated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels ...
ascopubs.org18d
Phase I Dose Escalation Study of Telatinib, a Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor 2 and 3, Platelet-Derived Growth Factor Receptor β, and ...
Comparison of Commission on Cancer–Approved and –Nonapproved Hospitals in the United States: Implications for Studies That Use the National Cancer Data Base We performed a phase I, pharmacologic, and ...
C&EN20d
Discovery of Imidazo[1,2-b]pyridazine Derivatives as Potent and Highly Selective Irreversible Bruton’s Tyrosine Kinase (BTK) Inhibitors
Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Research ...
ascopubs.org20d
Trend in Tyrosine Kinase Inhibitor Utilization, Price, and Out-of-Pocket Costs in Patients With Chronic Myelogenous Leukemia
CML, chronic myelogenous leukemia; PHC, Personal Health Care; TKI, tyrosine kinase inhibitor; USD, US dollars. Overall, the average annual part-D gross payment per 30 days of each TKI increased from ...
The Lancet25d
Immunotherapy plus tyrosine-kinase inhibitors in hepatocellular carcinoma
have transformed the treatment landscape of unresectable hepatocellular carcinoma (HCC), replacing multi-tyrosine kinase inhibitors (TKIs) as first-line therapies for most patients. Following positive ...
Cancer Research25d
Memory-like Natural Killer Cell and CD19 Antibody–Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute ...
1Research Institute Children’s Cancer Center Hamburg, Hamburg, Germany. 2Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany.
Science Daily27d
Discovery of dopamine receptors in a previously overlooked part of the brain sheds light on the complex circuitry for anxiety and depression
Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior. Mount Sinai researchers ...
ophthalmologytimes28d
ARVO 2025: The first phase 2 study to examine tyrosine kinase inhibitors for wet AMD
The research she presented focused on neovascular age-related macular degeneration (AMD). "This is actually the first phase 2 study looking at a tyrosine kinase inhibitor for wet AMD," Dr. Talcott ...
The Lancet28d
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
bCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA cDepartment of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana ...