Sleep-wake cycle modifiers:Ramelteon (Rozerem) is the newest prescription sleep medicine, and the only drug in its class. Ramelteon acts directly on the body's sleep-wake cycle, or circadian rhythm.

Ramelteon acts as an MT 1 and MT 2 melatonin receptor agonist, showing higher affinities for these receptors than does the natural ligand Ramelteon induces sleep initiation and maintenance, as ...

Nat Clin Pract Neurol. 2007;3(4):221-228. The metabolism and oxidation chemistry of ramelteon are entirely different from those of melatonin. Although ramelteon and melatonin are both substrates ...