As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: ...

A Ph.D. graduate student in biomolecular engineering at UC Santa Cruz, with a background in computer science and mathematics, ...

Say you want to study a new RNA: First, put the nucleotide sequence into one of the open-source, AI-based structure prediction tools available today. Then, take your sample to a small angle X-ray ...

Computational predictions of biomolecular structure via artificial intelligence (AI) based approaches, as exemplified by AlphaFold software, have the potential to model of all life’s biomolecules. We ...

DNA is fundamental to the biology of all life on Earth, but how many of us actually know what it is or what it's made of?

I investigated whether base reactivities and secondary structure models derived from them can explain some variability in the frequency of observing different nucleotide substitutions across millions ...

Researchers have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of catalytically active RNA.

Accurately predicting the secondary structure of Non-coding RNAs is crucial for understanding their biological roles. However, current methods face challenges in accuracy and computational efficiency, ...

The structure and function of nucleic acids The structure and function of nucleic acids Nucleic acids are essential biomacromolecules that carry or contain genetic information. They can be separated ...

BASH MaP quantitatively reveals alternative RNA tertiary structures by enabling dimethyl sulfate to probe the presence of nucleobase interactions on the Watson-Crick and Hoogsteen faces of single RNA ...

Chemical structure of a general RNA nucleotide triphosphate with a special alkyne bond (red) for use in click chemistry.

RNA's fate is determined by chemical modifications that affect its stability, structure and interactions and thereby its fate. More than 170 distinct RNA modifications have been described thus far.