News

Ancient Protein Breaks Biological Rules by Working in a Mirror World
A molecular reinterpretation of Alice in Wonderland reveals an ancient protein with a surprising function. In a ...
AI Cracks Secret Language of Sticky Proteins Linked to Alzheimer’s
Researchers have developed an AI system capable of predicting whether and why proteins form sticky clumps, a process ...
New understanding of protein processing could have implications for Alzheimer's and some cancers
Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, ...
A new method for studying mechanical proteins and their involvement in muscular disorders
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), led by Jorge Alegre-Cebollada, has developed an ...
eLife4d
The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides
The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...
Frontiers7d
A script to highlight hydrophobicity and charge on protein surfaces
Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research ... The script considers all molecules present in PyMOL individually. If the designation of the structure matches the given command ...
eLife10d
Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus
These fundamental findings offer a novel mechanism by which rubrerythrin tubules encapsulate encapsulin to prevent oxidative stress in Pyrococcus furiosus. However, there are a few reasonable concerns ...
Nature12d
The structure of the ferric siderophore binding protein FhuD complexed with gallichrome
we describe the 1.9 Å resolution structure of E. coli FhuD in complex with gallichrome. FhuD adopts a novel fold and represents a new class of iron binding ABC-type transport proteins.
The EMBO Journal13d
The amyloid‐β precursor protein: integrating structure with biological function
Proteolytic processing of the amyloid‐β precursor protein (APP) generates the Aβ amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current ...
C&EN19d
Dopant-Induced Charge Redistribution on the 3D Sponge-like Hierarchical Structure of Quaternary Metal Phosphides Nanosheet Arrays Derived from Metal–Organic Frameworks for ...
Faculty of Materials Science and Technology, University of Science, Ho Chi Minh City 700000, Viet Nam Center for Innovative Materials and Architectures, Ho Chi Minh City 700000, Viet Nam Vietnam ...
C&EN25d
Evaluating the Effect of Phosphorylation on the Structure and Dynamics of Hsp27 Dimers by Means of Ion Mobility Mass Spectrometry
Find more information on the Altmetric Attention Score and how the score is calculated. The quaternary structure and dynamics of the human small heat-shock protein Hsp27 are linked to its molecular ...
IEEE25d
GNNGO3D: Protein Function Prediction Based on 3D Structure and Functional Hierarchy Learning
Most of the existing methods only use the protein sequence but ignore the three-dimensional structure which is closely related to the protein function. And the hierarchy of protein functions is not ...