News

Ancient Protein Breaks Biological Rules by Working in a Mirror World
A molecular reinterpretation of Alice in Wonderland reveals an ancient protein with a surprising function. In a ...
AI Cracks Secret Language of Sticky Proteins Linked to Alzheimer’s
Researchers have developed an AI system capable of predicting whether and why proteins form sticky clumps, a process ...
New understanding of protein processing could have implications for Alzheimer's and some cancers
Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, ...
A new method for studying mechanical proteins and their involvement in muscular disorders
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), led by Jorge Alegre-Cebollada, has developed an ...
C&EN4d
Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues
‡ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States § Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of ...
eLife4d
The Structural Dynamics of IRE1 and its Interaction with Unfolded Peptides
The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...
C&EN4d
Outer-Sphere Contributions to the Electronic Structure of Type Zero Copper Proteins
Bioinorganic canon states that active-site thiolate coordination promotes rapid electron transfer (ET) to and from type 1 copper proteins. In recent work, we have found that copper ET sites in ...