Pyruvate kinase plays its role in the last step of the process, converting phosphoenolpyruvate into ATP and pyruvate. In its absence, red blood cells cannot make enough energy and start breaking ...

Although pyruvate kinase cells are destroyed predominantly in the liver, passage through the spleen creates an even more severe cellular disturbance, which enhances their hepatic destruction.

Discover the current pipeline candidates advancing through the clinic for the treatment of sickle cell disease.

The Food and Drug Administration (FDA) has granted Orphan Drug designation to FT-4202 (FORMA Therapeutics) for the treatment of sickle cell disease (SCD).

Poster Ex-vivo activation of pyruvate kinase by tebapivat reduces sickling and red blood cell adhesion in sickle cell disease PS2170 Saturday, June 14, 2025, 6:30 - 7:30 PM CEST ...

The disease is characterized by an accelerated destruction of red blood cells. Pyrukynd is a first-in-class, oral, selective PK activator.

Pyruvate kinase deficiency (PKD) is a rare, monogenic red blood cell disorder resulting from a mutation in the PKLR gene encoding for the pyruvate kinase enzyme, a key component of the red blood ...

Pyruvate kinase deficiency (PKD) is a rare, monogenic red blood cell disorder resulting from a mutation in the PKLR gene encoding for the pyruvate kinase enzyme, a key component of the red blood ...

A poster presentation with preclinical data demonstrating that tebapivat reduced red blood cell sickling and adhesion in blood samples from sickle cell disease patients, highlighting its ...