Candida auris is a dangerous fungal pathogen that has become a global health concern. It spreads easily in health care settings and can cause life-threatening infections, especially in patients with ...

A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

This article is cited by 15 publications. Brian M. Fox, Kazuyuki Sugimoto, Kiyosei Iio, Atsuhito Yoshida, Jian (Ken) Zhang, Kexue Li, Xiaolin Hao, Marc Labelle, Marie-Louise Smith, Steven M.

The DHODH inhibitor market is poised for steady growth, fueled by the rising burden of autoimmune and inflammatory diseases, along with incre ...

In this study, a new series of trihalomethyl-substituted pyrimidines and dihydropyrimidines were synthesized and tested as potential NTPDase inhibitors. For this purpose, synaptosomes from rat ...