Free protein S itself has anticoagulant effects: it inhibits the prothrombinase complex (factor Xa, factor Va, and phospholipid), which converts prothrombin to thrombin, and the tenase complex ...

Prothrombinase activity is required for the rapid, ... allowing the prothrombinase complex to function with APC, and (3) inhibiting APC slowly. Clinical trials show low thrombotic risk, ...

Factor Xa, factor Va, and calcium form a prothrombin-activating (prothrombinase) complex, which promotes the conversion of pro-thrombin to thrombin.

Because active site–mutated full-length fXa has the potential to bind fVa and act as a competitive inhibitor of the prothrombinase complex, we also deleted the membrane-binding GLA domain.

The prothrombinase complex (FVa:FXa) activates prothrombin to thrombin, the central protease of the clotting cascade. Fibrinogen is cleaved into soluble fibrin monomers by thrombin, ...

This BsAb replicates the function of coagulation factor VIII by promoting the formation of the prothrombinase complex and subsequent clot formation. Vabysmo (faricimab, Roche) ...

New research at the University of North Carolina at Chapel Hill has found that a fatty molecule on the surface of platelet cells is a regulator of blood coagulation. Besides its role in forming ...