You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized ...

To obtain high-quality structural or functional data, protein purification is typically required, which is both time and resource consuming, especially at the scale required to train ML tools. Here, ...

Plaques were analyzed by liquid chromatography–mass spectrometry for the presence of N-terminal fragments ... Identified peptides include signal and pro-peptides from synthesis and those from protein ...

As a ribosome substrate, proline reacts markedly slower when compared with other amino acids both as a donor and as an acceptor of the nascent peptide. Furthermore, synthesis of peptides ... to the ...

The beginning of protein synthesis is carried out by ribosomes ... and contain two different domains called the N and C terminals. The N terminal contains ATPase whilst the C terminal binds ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic ... proteins synthesized in ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic ... proteins synthesized in ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal ... in cells by ribosomes. This diverse set ...

The authors use a combination of proteome-specific protein complex structures and publicly available ribosome profiling data to show that cotranslational assembly is favored by large N-terminal ...