Figure 2: Classical versus electron-based methods for fragmentation of protein and peptide ions in tandem mass spectrometry. Top-down mass spectrometry has made valuable contributions to our ...

“Top-down” is the term used to describe an alternative proteomics approach, where proteins are not enzymatically digested into peptides. They are introduced ... interrogate structures of large ...

Scientists say a new ‘top-down ... with protein inference, where protein isoforms generated from native processes such as alternative splicing generate a number of identical tryptic peptides.

Rather than try to map ... peptides that CLIP indicated could bind to the protein and showed that four could effectively bond to and degrade their target. By destroying the protein, they can slow ...

The flexibility in their structure allows peptides to interact effectively with different receptors in the body, making them essential in signaling pathways. On the other hand, proteins are larger ...

"Understanding the structural diversity of nascent peptides formed in the ribosomal tunnel and their role in translational regulation can aid the elimination of bottlenecks in protein synthesis ...

Birmingham researchers have shown that PEPITEM, a naturally-occurring peptide (small protein), holds promise ... which break down bone. Disturbances to this tightly orchestrated process are ...