Expression of linear peptides bearing a cysteine-proline dipeptide sequence followed by glycolic acid results in self-rearrangement to a C-terminal diketopiperadine-thioester, ...

The authors concluded that the GGGGCC RNA and proline-arginine dipeptide work together in the same toxic pathway. Finally, Wen addressed the hypothesis that neurons need C9ORF72 to survive. She used ...

Other C9ORF72 dipeptides might precipitate those inclusions, Petrucelli suggested. “It will be of great interest to determine if that is true,” said Adrian Isaacs of University College London, who was ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction ...