Poliovirus infection occurs by the fecal-oral route. The host ingests the virus, which replicates in the alimentary tract. The virus is then shed in the feces. Most polio infections are ...

“We mucked around” with the structure of poliovirus, Andino told me, and figured out a way to make a modified version of type 2 that’s far stabler. It’s much less likely to mutate away ...