Data from phase II studies also suggest that pirfenidone, which has a different—yet largely unknown—mechanism of action, may also have activity in other fibrosing ILDs with a progressive phenotype, in ...

Nerandomilast is a preferential inhibitor of phosphodiesterase 4B (PDE4B) with antifibrotic and immunomodulatory effects, a ...

Although current treatments, such as pirfenidone and nintedanib ... Nanomaterial Examples Advantages Mechanism of Action Applications in Drug Delivery Liposomes Doxil (liposomal doxorubicin) ...

“Its mechanism of action is fairly unique in dermatology,” Bissonnette told Healio. “It is not a protein, it is a small peptide that can be given orally, and it blocks the interaction ...

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

The scarring of lungs is caused by some unknown origin. The exact mechanism of action of pirfenidone is not known. Pirfenidone is thought to reduce the lung fibrosis (scarring and thickening of ...

A research team now describes a new mechanism of action that kills cancer cells through ferroptosis. In a first, a Bochum-based team has produced a substance capable of sending cancer cells into ...

Mortality rates were also concerning, with IPF-related deaths at 13.4% for pirfenidone and 7.2% for nintedanib, while all-cause mortality was 20.1% for pirfenidone and 16.6% for nintedanib.

It is currently unknown whether a combination of treatments with different mechanisms of action may be preferable to individual ... Question 7 asked whether patients with SSc-ILD should be treated ...

The scarring of lungs is caused by some unknown origin. The exact mechanism of action of pirfenidone is not known. Pirfenidone is thought to reduce the lung fibrosis (scarring and thickening of ...

There are still many enigmas about the mechanism of action of metformin, the most prescribed drug to treat diabetes mellitus, also known as type 2 diabetes. Now, a review article published in the ...

One-year of high-dose AP01, Avalyn Pharma’s inhaled pirfenidone solution, slowed lung function decline in people with idiopathic pulmonary fibrosis (IPF). That’s according to top-line data from the ...