Scientists at the Broad Institute of MIT and Harvard have identified 4,208 previously unannotated open reading frames (ORFs) across 679 human-associated viral genomes using a high-throughput method ...

The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

At pH 9, FTIR spectra showed the loss of the α-helix structure, indicated by a peak ... to the 2-methylpropyl side chain of the leucine peptide, which decreased in intensity as pH increased.

By understanding how a helix is formed, we can gain deeper insights into how these structures influence the behavior of proteins in our bodies. In peptides, which are smaller fragments of proteins, ...

“It’s the same helix that you would find in peptides in biology, we’re just using it for non-biological reasons.” Polymers tend to adopt random configurations, but the backbone of the polymer can be ...

The specific secondary structure they observed formed a shape called the 310 helix. Because this work was conducted on peptides, the results lend themselves to a greater understanding of electron ...

These unique agents consist of natural peptides—a stretch of amino acids in a defined sequence—whose bioactive structure is chemically ... of the SARS-CoV-2 six-helix bundle into a stapled ...

Three decades ago, chemists created a synthetic family of DNA-like molecules, peptide nucleic acids (PNAs ... ability to unzip and slip inside a DNA helix, making them ideal tools for gene ...

2017). The hydrophobic end and the positively charged end are distributed on both sides, respectively, presenting a perfect amphiphilic α-helix structure. To exclude the influence of different amino ...

Researchers have created the first supermolecule consisting of a DNA helix and peptide ... they managed to change the chirality of the peptide to match DNA’s right-handedness meaning these two ...