During DNA replication, the classic double helix can temporarily rearrange into an alternative structure known as a DNA three-way junction (3WJ). These configurations form a well-defined central ...

Proteins need a priority code in their address labels to efficiently enter cell powerhouses. New research shows this code helps them recruit a helper protein, TOMM34, speeding up delivery crucial for ...

Tiny fat bubbles carrying gene therapy have successfully repaired DNA in the lungs and liver of animals with alpha-1 antitrypsin deficiency—a promising leap toward treating humans with this rare ...

Grilling seems simple, and in some ways, it is. You take a protein or some produce, season it however you like, and throw it on a sizzling hot surface until it tastes delicious. What could go wrong?

In a new study, Nobel laureate David Baker and colleagues detail new methods for targeting undruggable "disordered" proteins.

The dynamics of peptide α-helices have been studied extensively for many years, and the kinetic mechanism of the helix–coil dynamics has been discu ...

We have advanced this goal by designing a new family of amphiphiles based on coiled-coil 3-helix bundle forming peptide–poly (ethylene glycol) conjugates. The amphiphiles self-assemble into ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...