Objective Enteric glia activation has been reported to amplify intestinal inflammation via the enteroglial-specific S100B protein. This neurotrophin promotes macrophage recruitment in the mucosa, ...

The PPAR-γ coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological ...

Donor–acceptor Stenhouse adducts (DASAs) are a rapidly emerging class of visible light-activatable negative photochromes. They are closely related to (mero)cyanine dyes with the sole difference being ...

This choice is further supported by evidence in the literature indicating the involvement of the NF-κB/PPAR-γ pathway in jSSc and its role in systemic inflammation and fibrosis, which are hallmarks of ...

Schematic of processes and pathways contributing to age-related cardiac disease. As we age, multiple processes likely contribute to cardiac ... Rosenzweig A, Spiegelman BM. Transverse aortic ...

Describe yourself in three words or sentences. International recruitment manager at UoP London Pathway College. Collaborative team player who thrives in a dynamic, goal-driven environment. Avid reader ...

We describe a fully customizable and integrated target-specific “tiered” virtual screening approach tailored to identifying and characterizing novel peroxisome proliferator activated receptor γ (PPARγ ...

E75 modulates both Hippo and Notch pathways by binding with their transcriptional effectors—Sd, Yki, NICD, and Su(H) in Drosophila; TEAD, YAP/TAZ, RBPJ, and NICD in mammals—at a transcriptional and ...

The Fanconi anemia (FA) pathway is a critical DNA damage response mechanism responsible for the repair of replication barriers such as interstrand crosslinks (Raschle et al, 2008), R-loops (Hodson et ...