Our study reveals that the PD-1 receptor functions optimally as dimers driven by interactions within the transmembrane domain on the surface of T cells, contrary to the dogma that PD-1 is a monomer." ...

When PD-1 binds to its partner receptors on other cells, PD-L1 or PD-L2, it sends a signal to the T cell to paralyze its normal immune function. Block PD-1 Checkpoints, Shrink Tumors .

“Our study reveals that the PD-1 receptor functions optimally as dimers driven by interactions within the transmembrane domain on the surface of T cells, contrary to the dogma that PD-1 is a ...

The PD-1 receptor, a major immune checkpoint inhibitor whose signaling is the target of multiple blockbuster anticancer drugs, differs functionally between rodents and humans in previously unknown ...

Novel dual-cell bidirectional antibody engages two independent inhibitory receptors on multiple cell types in a single molecule. S-4321 is a low affinity PD-1 agonist with selective and functional ...

Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating ...

The three participants who responded to PD-1 blockade started with serum PSA levels of 46, 71 and 2,503 ng/ml. These PSA levels plummeted to less than 0.1 ng/ml after treatment, and these three ...

Of these, the PD-1 epitope sequence 92-110 significantly reduced tumor growth in an animal colon cancer tumor model and was chosen for the PD1-Vaxx inhibitory vaccine. Key findings: ...