Connecting the outside-of-the-cell portion of PD-1 with the inside portion is the transmembrane segment. Many immune receptors function in pairs called dimers, but to date, PD-1 has been thought ...

Combination treatment could also benefit patients with lung, bowel, pancreatic and other solid cancers who don’t respond to ...

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

PD-1 deficiency enhances Treg cell pro-tumor function Lim et al. demonstrate that Treg cells deficient in PD-1 occupy key spatial niches within the TME, with regulatory subsets organized near tumor ...

In 1992, graduate student Yasumasa Ishida discovered PD-1, marking the beginning of a journey that would make this molecule a ...

When PD-1 binds to its partner receptors on other cells, PD-L1 or PD-L2, it sends a signal to the T cell to paralyze its normal immune function. The immune system is equipped to suppress tumors on ...

Stuart Tangye, Head, Immunology and Immunodeficiency Lab, Garvan Institute of Medical Research The researchers focused on the molecule PD-1, which acts as a 'handbrake' on the immune system ...

Much of our understanding of PD-1’s functions, like many proteins, comes from studies in mice, based on the assumption that rodent and human biology operate similarly. However, human and mouse PD-1 ...

Hong Kong's Akeso has ended the week on a high note, with an FDA approval for its PD-1 inhibitor penpulimab and more data on PD-1/VEGF bispecific antibody ivonescimab. Penpulimab has picked up a ...