Scientists dive into the genomes of whales, elephants, and other animal giants looking for new weapons in the fight against ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review ...

PNC-27 is a synthetic peptide composed of 32 amino acids. It is engineered to contain the MDM-2 binding domain of the tumor ...

Hepatic biliary adenofibroma is an exceedingly rare biliary neoplasm that primarily affects adults. It typically presents as a solitary mass composed of low-grade microcystic and tubuloglandular bile ...

Previous research revealed that nuclear factor of activated T cells 1 (NFAT1) is a novel regulator of the mouse double minute 2 homolog (MDM2) oncogene, which acts by directly binding to the MDM2 P2 ...

A new research paper was published in Oncotarget , Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells." ...

Wu now works at ByteDance’s Seed department, which the Beijing-based company started in early 2023 after OpenAI’s ChatGPT sparked widespread interest in large language models and generative AI ...

The University of Melbourne and affiliated organizations presented the development of a new reporter mouse model designed to study the role of MDM2 and its transcriptional regulation in p53-mediated ...