Together, the current studies reveal a previously unknown role for ESCRT-III in re-forming the nuclear envelope. The association, albeit transient, between ESCRT-III and nuclear membranes raises ...

"The requirement for the presence of histones may help the cell control where the mitotic spindle and the nuclear envelope form," Funabiki says. "This is particularly important for large cells ...

Figure 1: ESCRT-III localizes to the forming nuclear envelope. Figure 3: UFD1 directs NE-localization of CHMP2A. A SnaBI/NotI fragment from pH2B-mCherry-IRES-Neo3 (a gift from U. Eggert ...

Researchers reveal that Merkel cell polyomavirus bypasses normal nuclear entry routes by exploiting the temporary breakdown ...

This transport of large goods is similar to how large macromolecules are trafficked out of the cell nucleus via an export pathway termed nuclear envelope budding. This process “allows for large ...

Made up of two lipid bilayers called the inner and outer nuclear membrane, the nuclear envelope protects DNA from damage by ... molecular machines that penetrate both nuclear membranes to form ...

Nuclear envelope ruptures are rapidly repaired in the nucleus, but persist at aberrant, nuclear compartments, such as micronuclei and DNA bridges, that form around mis-segregated chromosomes.

The cell nucleus is the site of many important biological functions of the eukaryotic cell. These processes include transcription, replication, splicing and ribosome biogenesis. The effect of ...