Feedback loops exacerbate damage: Impaired autophagy creates a feedback loop where protein aggregation further inhibits autophagy, accelerating neurodegeneration in diseases like Alzheimer’s and ...

Researchers are building out the repertoire of chemical reactions, using light. They report a method using photobiocatalysis to produce non-canonical (not naturally occurring) amino acids that are ...

In a paper published in the journal Nature, chemistry professor Yang Yang and collaborators at the University of Pittsburgh report a method using photobiocatalysis to produce non-canonical (not ...

Conclusions: Hypoxia and glucose deprivation induce non-canonical PANoptosis that is initiated by RIPK3 and independent of ASC. The PANoptotic tumor cells suppress anti-tumor immunity through ...

They also identified that non-canonical lipidation of a subfamily of autophagy-related protein 8 (ATG8s) molecules -- the key autophagy proteins -- known as Gamma-aminobutyric acid receptor ...

Importantly, elevated canonical autophagy alters the fate of B GC cell differentiation without affecting GC formation or cell survival in RUBCN B-KO mice.

Noncanonical Amino Acids Inspire the Development of Novel Drugs Commercial platforms for protein therapeutics are being built on academic research that has expanded the genetic code behind cell ...

Secondly, the conventional method of synthesizing non-canonical amino acids is a complicated multi-step process. “Our process shortcuts non-canonical amino acid synthesis by three to five steps. For ...

Autophagy, one of the arms of proteostasis, influences aging and age-related diseases. Recently, the discovery of additional roles of autophagy-related proteins in non-canonical degradation and ...

Autophagy is a natural process in which your body breaks down and cleans out damaged cells. It is triggered by fasting and has been promoted for weight loss and longevity, although there is no ...

For canonical autophagy, although various types of selective autophagy have thus far been discovered, such as mitophagy, lipophagy and ER-phagy, the molecular mechanisms and cargo receptors, which ...

In the body, a cellular process called autophagy occurs regularly to "de-clutter" our cells. Recently, researchers in Japan have shed new light on the relationship between this process and the ...