Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have made one of the most ...

In this study, we investigated the interplay between cigarette smoke, DNA damage and repair, focusing on the Nucleotide Excision Repair (NER) protein ...

When it comes to helping NASA scientists better understand the effects of space travel on the human body, fruit flies are the ...

Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States Graduate Program in Chemistry and Chemical Biology, University of California, Davis ...

A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital ...

The research, published today as a Reviewed Preprint in eLife, is described by the editors as a landmark study with compelling evidence on how an important player in DNA repair – the RAD51 filament – ...

Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA damage responses (DDR) and a pathway coordinator and structure-specific endonuclease in nucleotide excision ...

A NEW study presented at ESMO Breast 2025 explores the impact of inherited mutations in DNA repair genes on the effectiveness of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in hormone ...

More information: F. Li et al, Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair, Nature Communications (2025). DOI: 10.1038/s41467-025-59323-y ...

Figure 1: Mechanism of nucleotide excision repair and base excision repair. The protein factors that are required for TCR and general genome repair (GGR) of DNA damage fall into two broad groups.

The team had previously found that LEM-3 plays a critical role in resolving persistent DNA bridges, acting as a last resort when other repair pathways fail. LEM-3 was specifically observed to ...