In this study, we investigated the interplay between cigarette smoke, DNA damage and repair, focusing on the Nucleotide Excision Repair (NER) protein ...

Figure 1: Mechanism of nucleotide excision repair and base excision repair. The protein factors that are required for TCR and general genome repair (GGR) of DNA damage fall into two broad groups.

Efficient DNA repair mechanisms have evolved to ... xeroderma pigmentosum complementing protein B; NER, nucleotide excision repair; pol η, polymerase η; SSB, single-strand break; TCR ...

A new study uncovers how working at 35,000 feet may disrupt DNA repair and immune function in flight attendants, offering fresh insights into the health risks faced by cabin crews and the urgent ...

The stabilization of DNA repair and stress factors could ... Molecular mechanism of nucleotide excision repair. Genes Dev. 13, 768–785 (1999).

An outline of the nucleotide excision repair pathway, which includes global genomic repair (1B) and transcription-coupled repair (1A). The damaged base in the DNA is indicated by a green star.

Department of Molecular and Precision Medicine, Penn State College of Medicine, Pennsylvania State University, Hershey 17033, Pennsylvania, United States ...

A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are ...

More information: F. Li et al, Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair, Nature Communications (2025). DOI: 10.1038/s41467-025-59323-y ...