In cultures of both human cells and living mice, engineered regulatory T cells were able to simmer down gluten-reactive effector T cells that cause the characteristic autoimmune response seen in ...

A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study ...

No comprehensive industry-wide safety-testing procedures have been adopted for CAR-T therapies. The onus is still on drug developers to make sure their constructs are safe.

The Charles River models NCG-hIL2 and NCG-hIL15 are built on the NCG background, which lacks functional/mature T, B, and NK cells, and has reduced macrophage and dendritic cell function.

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse ...

An infusion of CAR T cells designed to target senescent cells was not only able to improve metabolic function in older mice and mice prematurely aged by a high-fat diet, but a single dose given to ...

An immunofluorescence image of an aged mouse liver. Expression of β-galactosidase (white) and uPAR (yellow) in senescent cells serve as target for engineered CAR T cells. Elimination of these ...

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

A new study shows that treatment with an immune-boosting protein called interleukin 7 (IL-7) in combination with radiation improves survival in mice with glioblastoma. The study in mice suggests ...

Laboratory research led by MSK and Cold Spring Harbor Laboratory demonstrates the potential for CAR T cells to improve “healthspan” by eliminating senescent cells associated with aging-related ...