A vaccine protects more than 100 million infants each year from severe tuberculosis (TB), including the fatal brain swelling ...

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

The Charles River models NCG-hIL2 and NCG-hIL15 are built on the NCG background, which lacks functional/mature T, B, and NK cells, and has reduced macrophage and dendritic cell function.

CAR-T cells are specialized immune cells genetically modified to recognize and attack cancer cells. Researchers at Nagoya University in Japan and their collaborators have developed new CAR-T cells ...

Satri-cel, a CLDN18.2-targeted CAR T-cell therapy, nearly doubles progression-free survival in patients with previously treated gastric or gastro-esophageal junction cancer, according to a ...

Contrary to long-standing beliefs, T cells—key immune cells—have been discovered in the healthy brains of both mice and humans.

Modified, autologous T-cell immunotherapies have been transformative in the treatment of hematologic malignancies with several approvals of chimeric antigen receptor T-cell therapies to treat lymphoma ...

A phase 2 dose expansion study of ZG006, a trispecific T cell engager targeting CD3/DLL3/DLL3, as monotherapy in patients with advanced small cell lung cancer.. If you have the appropriate software ...

CAR-T therapy caused mild cognitive impairment in mice with cancers originating in, metastasizing to and located completely outside the brain.

Using sophisticated bone marrow chimera studies, we defined the main cellular sources of disease mediators, and by utilising specialised knockout mice we uncovered a niche dynamic between two key ...

eLife Assessment This study reanalyzed previously published scRNA-seq and TCR-seq data to examine the proportion and characteristics of dual-TCR-expressing Treg cells in mice, presenting some useful ...

Subcutaneous infection by lymphocytic choriomeningitis virus (LCMV) is characterized by skewed CD4 + T-cell polarization, as well as severely impaired differentiation of T follicular helper (T FH) ...