The STING pathway also activates the NF-κB signaling cascade, further promoting inflammation. The STING pathway's role in NAFLD progression is multifaceted. High-fat diet-induced NAFLD has been ...

A new study in the Journal of Clinical Investigation provides a link between molecular signaling pathways in the gut, the intestinal microbiome, and development of NAFLD. Frank Gonzalez and ...

Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation ...

Researchers have now found a signaling pathway in cells that play an important role in the development of fatty liver disease. In Switzerland, about every tenth adult suffers from morbid obesity.

The results of this study demonstrate that HO-1 helps reduce hepatic fibrosis associated with NAFLD by modulating the SIRT1/TGF-β/Smad3 signaling pathway. Insights into the interactions between ...

Like bile acids, they too play a role in signaling pathways that impact metabolic disorders, including NAFLD. Lipid profiling in animal models and human patients has shown a correlation of ...

HCV has also been associated with dysregulation in insulin signaling and lipid metabolism ... non-alcoholic fatty liver disease is now becoming a more frequent, concomitant diagnosis in HCV ...

Taking control of this pathway through the Recombination signal binding protein for immunoglobulin kappa J region (Rbpj) protein, the scientists were able to reroute the production of these ...

will present new data from Axcella’s AXA1125 liver program at the Integrated Pathways of Disease in NASH and NAFLD Keystone Symposium, taking place January 20-24, 2019 in Sante Fe, NM.

The pathway outlines a 4-step screening process for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). A new clinical care pathway is available for clinicians ...