"Our pioneering science relating to the mechanics of cardiac muscle ... myosin (S1) as does aficamten, a cardiac myosin inhibitor also developed by the Company. Unlike aficamten, the inhibitory effect ...

In the process of identifying genes regulated by the cardiac homeobox transcription factor Nkx2-5, we identified a gene product highly homologous to the previously characterized skeletal and smooth ...

Myosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain ... is associated with RhoA/Rho‐associated kinase/MYPT1 signaling upregulation in smooth ...

Primary cultures of cardiac ventricular myocytes from ... EcoR1 fragment of constitutively active rabbit skeletal muscle myosin light chain kinase (tSkMLCK, a gift of J.T.Stull) was subcloned ...

Introduction: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC 20) is a critical switch leading to SM contraction. The canonical view held that only the short isoform of myosin ...

Cardiac-specific myosin light chain kinase (cMLCK), encoded by MYLK3, regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light chain. However, the ...

Upregulation of the nonmuscle myosin light chain kinase (nmMLCK) might contribute to the development of pulmonary arterial hypertension (PAH), according to a new study published in the International ...

Jurczyszyn A, Rajtar-Salwa R, Sorysz D, et al. Reversing the poor prognosis of primary amyloid light-chain amyloidosis with cardiac involvement. Pol Arch Intern Med ...

Both smooth muscle (SM) and non-muscle (NM ... This sustained contraction was mediated by NM myosin RLC (NM RLC) phosphorylation by myosin light chain kinase (MLCK). NM myosin II was expressed ...