Experts reassess endpoints, patient selection, targets, and timing for the development of successful immune-based treatments ...

Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem ...

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways ...

The acetylation in the TIR domains complex emerged as a crucial factor for the TLR4/MAL/MyD88 signal pathway activation. Our investigations revealed that CBP-mediated TIR domain complex acetylation ...

Institute of Food Science and Technology, Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs of P. R. China, Chinese ...

In conclusion, MyD88 plays a pivotal role in regulating breast cancer cell proliferation through the activation of multiple key signaling pathways. This highlights MyD88 as a significant potential ...

where a signaling pathway may impair or augment another signaling pathway. Here, we report a negative feedback regulation of signaling through the key innate immune mediator MyD88 by ...

Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 ...

and biases TLR4 signaling towards the MyD88 pathway. Finally, we demonstrate that human carriers of a dominant-negative TLR5 allele have decreased inflammatory response to O 3 exposure in vivo and LPS ...