Targeted Oncology connects oncology professionals with updates on immunotherapy, biomarkers, cancer pathways, and targeted ...

BeOne Medicines Ltd. (NASDAQ: ONC; HKEX: 06160; SSE: 688235), a global oncology company, will present new clinical data from three cornerstone hematology assets at the European Hematology Association ...

Progression-free survival ... a variety of tumor cell types and plays an important role in tumor cell proliferation and tumor blood vessel formation. "Zongertinib has the potential to reset the ...

This kinase sends constant growth signals, causing uncontrolled white blood cell proliferation. Gleevec works by blocking the ATP-binding site of BCR-ABL, preventing leukemia cell growth. Most TKIs ...

HCL variant is also called splenic B-cell lymphoma with prominent nucleoli. The V600E missense mutation in the cytosolic serine–threonine kinase BRAF leads to its constitutive activation ...

In this issue, Yan et al (2024) demonstrate that FLT3 activation promotes mitobiogenesis and leukemia progression through a posttranslational control mechanism, linking cell metabolism ... settings ...

Acute myeloid leukemia ... FLT3 mutation. The FLT3 gene manages the production of fms-like tyrosine kinase 3 (FLT3). FLT3 is a protein that manages the growth and division of various cells ...

The objectives are as follows: The objective of this review is to assess the effects of Bruton tyrosine kinase (BTK) inhibitors in the treatment of adults with chronic lymphocytic leukemia (CLL), ...

Among them, tyrosine kinase inhibitors (TKIs ... signaling pathways that undertake the signaling transduction to sustain proliferation and survival of the tumor cell. Variants in cytochrome 450 ...