For those with chronic myeloid leukemia ... mutation known as the Philadelphia chromosome. This mutation drives uncontrolled cell growth by creating a hyperactive enzyme, Abl1 kinase.

and the role these mechanisms play in cancer (particularly leukemia and melanoma). Sean's lab discovered a series of key regulators that distinguish stem cell self-renewal from the proliferation of ...

Princess Margaret Cancer Center at University Health Network-led researchers constructed a detailed single-cell atlas of ...

The investigational oral tyrosine kinase inhibitor (TKI) zongertinib showed promise in patients with previously treated HER2 ...

Boehringer Ingelheim unveiled new data from its top oncology prospect zongertinib, further backing the drug’s prowess in ...

A new study finds that statin use significantly improves survival outcomes in patients with chronic lymphocytic leukemia or ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan Kettering Cancer Center (MSK) found that common splicing factor mutations in myelodysplastic syndrome or acute myeloid leukemia ...