Nature8d
Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR–ABL tyrosine kinase
We have found that inhibition of the BCR–ABL tyrosine kinase, either by mutation or by the drug ... to selectively kill chronic myelogenous leukemia cells. Here we show that STI571 has a second ...
Nature15y
Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia
At a once-daily dose and a relatively short half-life of 3–5 h, tyrosine kinase ... leukemia: it clearly inhibits the proliferation of Bcr/Abl P190-expressing mouse ALL cells and, to a lesser ...
Too Old to Operate8d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...