HK) presented the mechanism of action (MOA) research findings of its innovative bispecific antibody, AK132, targeting both Claudin18.2 (CLDN18.2) and CD47. AK132 is an asymmetric bispecific ...

Thus, this engineering approach will be a useful tool for design of IgG antibodies with tailored mode-of-action towards a specific target and indication. “Development of the next generation of ...

Mode of action of the new microscopy method LLS-TDI-DNA-PAINT. On the top right, the RTX antibody was visualised on a Raij-B cell: it is easy to see how it links the CD20 molecules in the membrane.

Interleukin (IL)-15 is a cytokine with different modes of action ... of clinical testing of humanized anti-IL-15 monoclonal antibodies. "IL-15 is an ambivalent cytokine, and understanding its ...

a bispecific antibody targeting EGFR and LGR5, in the journal "Cancers." The study highlights the mechanism of action of petosemtamab, which is designed to combat cancer by blocking EGFR ligands ...

This mechanism of action opened up the floodgates ... The system is so named as it is known to “complement” the antibacterial action of antibodies, although it can also be activated in ...

WILMINGTON, DE — Incyte (Nasdaq: INCY) is set to present pivotal data from its hematology/oncology portfolio at the 2025 ...

However, the exact mechanism by which bulevirtide interacts ... the researchers first generated an antibody fragment that specifically recognises the NTCP-bulevirtide complex and makes it ...

Studies have reported that COVID-19 vaccines confer immune protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by inducing antibody (Ab)-based humoral and T ...

The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down. “Our results establish an outside-in signaling mechanism that provides fundamental ...

EVGN), today announced the breakthrough discovery of a novel Mode of Action (MoA) active against Zymoseptoria tritici, the fungal pathogen responsible for Septoria tritici blotch (STB), one of the ...