Fibrolamellar hepatocellular carcinoma (FLC) has no approved treatment and occurs mostly in adolescents and young adults - KUALA LUMPUR, Malaysia, July 07, 2025 (GLOBE NEWSWIRE) -- Cyclacel ...

We propose an updated model for mitotic spindle orientation in which aMT anchoring at the cell cortex is mediated by palmitoylated importin α through its interaction with NuMA (Fig. 6).

Mitotic spindle assembly and chromosome segregation are dynamic processes that require microtubules (MTs), MT-associated motors, MT-binding proteins, and chromosomes to coordinate with each other.

Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Many fundamental processes of life, and their synthetic counterparts in nanotechnology, are based on the autonomous assembly ...

A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and ...

Lastly, we demonstrate that manipulating spindle geometry can alter mitotic and metaphase duration, consistent with a model prediction. Our results suggest that spindle size does not always scale with ...

A prototypical example of cytoskeletal remodeling is mitotic spindle assembly, where microtubules nucleate, undergo dynamic instability, bundle, and organize into a bipolar spindle. Key mechanisms of ...

The mitotic spindle is flexible and is made of microtubules, which are in turn made of the protein subunit, tubulin. Metaphase: The nuclear membrane dissolves and the mitotic spindle latches on to ...

Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein.