The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

A gene that regulates the development of roots in vascular plants is also involved in the organ development of ...

We have recently shown that Casein Kinase 1 (CK1) promotes timely progression through mitosis by phosphorylating FAM110A leading to its enrichment at spindle poles. However, the mechanism by which ...

While the intricate dynamics of mitosis is well-studied in the so-called somatic cells -- the cells that have a specialized function ... process is the mitotic spindle, which is made of ...

The C‐Nap1 anchored Ninein functions independently of Rootletin ... Furthermore, these early mitotic defects lead to prolonged SAC activation and eventually to multipolar spindles and chromosome ...

Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to aneuploidy and cancer. Using in vitro reconstitution assays we show ...

and mitotic spindle positioning, respectively. To achieve its variable functions, NuMA interacts with multiple factors, including DNA, microtubules, the plasma membrane, importins, and cytoplasmic ...

Centrosomes separate, and microtubules form a bipolar spindle to array chromosomes at metaphase ... adhesion and changes in intracellular pressure, to drive mitotic rounding. And we explore the ...

The essential functions required for mitotic spindle assembly and chromosome biorientation and segregation are not fully understood, despite extensive study. To illuminate the combinations of ...

The researchers think that this function might be made possible by ... role for centrioles in PCM accumulation, and therefore mitotic spindle assembly.” The study shows the vital role of ...