Fibrolamellar hepatocellular carcinoma (FLC) has no approved treatment and occurs mostly in adolescents and young adults - KUALA LUMPUR, Malaysia, July 07, 2025 (GLOBE NEWSWIRE) -- Cyclacel ...

Sadie Wignall, a professor at Northwestern University, delves into the secrets of spindle formation in acentrosomal oocytes in her seminar at Hopkins. On Thursday, Oct. 12, Associate Professor in the ...

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells.

Proliferative defects resulted from a mitotic failure, characterized by the presence of extra-centrosomes and the formation of multipolar spindles, causing abnormal chromosomes congression during ...

The Plo1 bypass by the reduction in glucose uptake was dependent on another kinase (casein kinase I), which potentiated spindle microtubule formation. This study illustrates a rare experimental bypass ...

Embryos produced by somatic cell nuclear transfer (SCNT) display low term developmental potential. This is associated with deficiencies in spindle composition prior to activation and at early mitotic ...

Angiogenesis requires coordinated endothelial cell specification, proliferation, and collective migration. The orientation of endothelial cell division is tightly regulated during the earliest stages ...

Synopsis The multifunctional adaptor protein ALIX is recruited to centrosomes, where it plays a previously unrecognized, evolutionarily conserved role in regulating mitotic spindle orientation, by ...

Synopsis Meiotic spindles in mouse oocytes form ‘inside‐out’, ending with a barrel‐shaped pole. Shifting spindles towards a mitotic‐like ‘outside‐in’ mode leads to severe chromosome alignment defects, ...

Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin ...