Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. The exact mechanism of action of metoclopramide in the ...

Metoclopramide is currently the only medication that is US FDA approved for the treatment of gastroparesis. [] It was first described by Louis Justin-Besaçon and Charles Laville in 1964 and has ...

The mechanism of sedative action of metoclopramide may be the result of a central antidopaminergic effect that metoclopramide exerts by antagonizing dopamine D2 receptors 11.