Methotrexate, a structural analogue of folate ... In order to generate purines, SARS-CoV-2 post-transcriptionally remodels host folate metabolism. In an in vitro system using African green monkey, ...

A-Sense Lab, Department of Bioscience Engineering, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium NANOlab Center of Excellence, University of Antwerp, Groenenborgerlaan 171, 2020 ...

In an interview last month with former Fox News journalist Megyn Kelly, Makary unveiled plans for a new regulatory pathway for rare disease drugs, allowing for their conditional approval based on a ...

Objective: Methotrexate (MTX) serves as a cornerstone therapy for primary central nervous system lymphoma (PCNSL). However, the considerable intra- and inter-individual variability in its ...

Cellular Pathway of Methotrexate MTX affects enzymes in several important pathways, such as the folate and adenosine pathways involved in purine and pyrimidine metabolism within the cell.

Now new research, published at the ATS 2025 International Conference and in the American Journal of Respiratory and Critical Care Medicine, finds that methotrexate provides a comparable alternative.

The long pathway to cell organization and growth Date: May 15, 2025 Source: University of California - San Diego Summary: Sterols are among the most abundant lipids in eukaryotic cells, yet are ...

Now, a new study combining data from two separate phase 1 clinical trials shows that a targeted vaccine strategy can successfully activate early immune responses relevant to HIV, and in one trial ...

In this editorial, the authors describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder. 2 Department of Chemistry and Biochemistry, University of ...

Caption: Few people stopped by the Georgia Pathways booth at the Washington County Health Fair in Sandersville, Georgia, in March. Credit: Nicole Craine for ProPublica Our newsletters uncover the ...

† Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, P. R. China ‡ Research Center of Biomedical Engineering, College of Materials, Xiamen ...