These results suggest that metformin might exert cardioprotective effects beyond its glucose-lowering action such as either activation of AMP-activated protein kinase (AMPK) or elevation of nitric ...

Nevertheless, the specific underlying mechanism needs to be clarified. Historically, metformin should not be used in patients with heart failure due to lactic acidosis risk (21). Nowadays, clinical ...

† Key Laboratory of Colloid and Interface Science, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of ...

A major study from scientists in China is shifting how we think about aging. The long-held belief that aging is a one-way ...

Several important questions remain in this model, including the requirement of AMPK activation for the observed therapeutic efficacy, the direct impact that metformin-induced Parkin has on phenotype ...

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey ...

(RTTNews) - CytoDyn Inc. (CYDY.OB), a biotechnology company, Tuesday announced new data suggesting a novel mechanism of action of leronlimab for the treatment of solid tumors. CytoDyn analyzed ...

She adds, “This preliminary work opens exciting avenues for future research to clarify the underlying mechanisms and to develop new improved therapies focusing on increasing energy expenditure ...

Our tournament offers insights into which strategies are most effective and why, identifying key mechanisms of action. Our findings are relevant to psychological theories of behavior change, ...

Figure 1. Schematic representation of the intestinal barrier and mechanism of action of mucoprotectants. The intestinal barrier comprises the mucus layer, the intestinal–epithelial barrier and the gut ...