Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

Volume 17, Issue 5, on May 1, 2025, titled "Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets." ...

Although the detailed mechanism for the stimulation of intra-islet GLP-1 secretion remains to be elucidated and further studies are required, as far ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...

Hopes for the use of oxytocin as a therapy for mood and attachment disorders have been confounded by the wide-ranging effects on social behavior revealed by human studies.

During embryonic development, thousands of cells divide and move as one. Understanding the mechanisms that coordinate this collective behavior remains a significant challenge in biology and the ...

Citation: Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes (2025, May 30) retrieved 23 June 2025 from https://medicalxpress.com ...

This work reports that cationic micelles formed by cationic trimeric, tetrameric, and hexameric surfactants bearing amide moieties in spacers can efficiently kill Gram-negative E. coli with a very low ...

DNA replication is a fundamental process required of all cell types (1–3).Replicative polymerases (Pol), such as the leading-strand polymeraseε (Polε) and lagging-strand Polδ, synthesize DNA with ...