An examination into the drug resistance mechanisms at work in P. falciparum, the malaria parasite species which accounts for 90% of deaths worldwide.

As drug developers turn toward more targeted and mechanism-based approaches, understanding how therapeutics alter transcriptional activity is essential. For potential candidates that act on the ...

Exploring the efficacy and mechanism of action of combined pan-Raf and MEK inhibition in halting the growth of non-V600 BRAF mutated tumors.. If you have the appropriate software installed, you can ...

FDA Clearance of Investigational New Drug Application Received for Novel EGFR/HER3 Bispecific Antibody-Drug Conjugate AVZO-1418/DB-1418 PR Newswire SHANGHAI and SAN DIEGO, May 22, 2025 ...

The study highlights the mechanism of action of petosemtamab, which is designed to combat cancer by blocking EGFR ligands, promoting internalization and degradation of EGFR in LGR5+ cells, and ...

This latest research reinforces an additional mechanism of action beyond direct cancer destruction and indirect immune stimulation, stripping away one of cancer's final defence mechanisms.

“This elucidation of MIPLYFFA’s ® highly differentiated mechanism of action marks a critical step in understanding its interactions with Niemann-Pick disease type C (NPC) at a cellular level,” said ...

IgA nephropathy drugs that work via other mechanisms include delayed-release budesonide (Tarpeyo), sparsentan (Filspari), and iptacopan (Fabhalta).

Previously known as JNJ-2113, icotrokinra (Protagonist Therapeutics, Johnson & Johnson) has a very specific mechanism of action for the treatment of moderate to severe plaque psoriasis, according ...

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

There are many assets with many different mechanism of actions going into the EGFR development pipeline, which is quite exciting. The most advanced, I will say, have to be antibody drug conjugates.

Therefore, the authors performed a comprehensive review of recent literature on the antitumor effects of glabridin and its novel drug delivery systems, covering the antitumor mechanism, action targets ...