Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

A bacterial syringe delivers a deadly enzyme The mechanism of action of Tc toxins has only ... structure of the Tc toxin subunits and their assembly by cryo electron microscopy (cryo-EM) enabled ...

The company's lead product, ASM-024, has a novel multi-functional mechanism of action with nicotinic and muscarinic effects and has demonstrated anti-inflammatory effects, bronchoprotection and ...

Antiinflammatory homeostatic mechanisms reverse these processes as the infectious agent is cleared by the innate and adaptive immune systems. The hypothalamic–pituitary–adrenal axis and ...

By fusing two further cryo-EM snapshots of TccC3 bound to F-actin and of the modified F-actin alone, the scientists have uncovered the enzyme’s unique mechanism of action. “TccC3 acts like a boxer who ...