Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of ...

Molecular analysis of Myc-induced tumors has established that some of these apoptotic pathways are essential checkpoints that guard the cell from cancer, as they are selectively bypassed during ...

The cancer-causing form of the gene Myc alters ... These three proteins represent a downstream target in the Myc pathway at which to aim drugs. Roughly 25 percent of all neuroblastoma cases ...

and synthetic lethality-wherein pathways essential to MYC-overexpressing cells are selectively disrupted. These methods aim to exploit the vulnerabilities of cancer cells that depend heavily on ...

UC researchers have found how the MYC oncogene fuels lymphoma by altering cell metabolism, paving the way for targeted ...

Cancer cells with elevated MYC expression often exhibit ... A current challenge is to identify additional synthetic lethal targets in these signaling pathways downstream of MYC. To date, both ...

a team of Moffitt Cancer Center researchers demonstrated a possible alternative approach. They showed that MYC activates a downstream pathway that chemically modifies a protein called eIF5A ...

In a new study published in the journal Cell Reports Medicine, a team of scientists at Baylor College of Medicine took a closer look at the molecular pathways metastatic cancer cells use ... factor ...

Research from the University of Cincinnati reveals how the MYC oncogene alters PRPS enzymes, impacting redox homeostasis and ...

However, the molecular pathways and mechanisms underlying metastasis are not fully understood. Cancer is characterized ... and the transcription factor Myc. The Myc gene is a known proto-oncogene ...

But eventually, the immune-attracting pathways are turned off ... some of the immune cells affected by excess MYC expression in prostate cancer -; are already in development and are potential ...

PHILADELPHIA - Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman ...