De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

BORC-ARL8 is an essential regulatory factor in the fusion of lysosomes with autophagosomes ... presents significant challenges in structural biology. To overcome technical challenges such as ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

When functional, a lysosome can break down large sugars into ... by improving our knowledge of the complexities of human biology.

Once fats are broken down in the lysosome, they serve several important roles in the cell. One is membrane repair and maintenance. The broken-down fat components, such as phospholipids and ...

I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) ...

Among these, the transcription factors EB (TFEB) and E3 (TFE3) caught Tan’s attention, because their activation coincided with genes that increased lysosome production. TFEB is also an ancient ...