Lubiprostone acts on type-2 chloride channels located on the apical side of gastrointestinal epithelial cells to promote electrolyte and fluid secretion into the small intestine and may also ...

Lubiprostone: Type 2 chloride channel (CCl2) activator. Chloride secretion in the intestinal lumen followed by passive diffusion of sodium and water. Nausea, headache.

About this study. The purpose of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are ...