Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big ...

Biofilms are conglomerates of bacteria and other organisms, which are feared in medicine as well as other areas because they ...

SLC35B1 transports ATP into the ER, and its structure offers potential for targeted therapies in diseases linked to ER stress ...

The accumulation of lipid-rich plaques on arterial walls eventually leads to the rupture or erosion of vulnerable lesions, triggering excessive blood clotting and leading to adverse thrombotic events.

We discuss the genetic and environmental regulators of fibrin structure in relation to thrombotic disease. In addition, we discuss the implications of fibrin structure for treatment of thrombosis.

This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

Sensory memory impairment and lipid oxidation were observed in C. elegans upon ingestion of these synthetic, exogenous prion-like sequences. The remaining 60% of positive prion-like sequences, with ...

1989, 1991, Bozza & Weller 2001). Moreover, PAF but not its precursor and metabolite, lyso-PAF, that shares the lipid structure of PAF but has no receptor agonistic activity (Prescott et al. 2000), ...

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Successful drug development for bioactive lipid targets requires a deep knowledge of the biology and pathobiology ... and metabolic profiles into the drug structure (Fig. 2).

The findings have been published in Communications Chemistry. Lipid nanoparticles (LNPs) came to prominence for the delivery of RNA with the success of the Moderna and Pfizer BioNTech COVID-19 ...

Scientists have developed a method for analysing the structure of lipid nanoparticles that could be used to improve vaccine and drug delivery, targeting a wide range of health issues. A team led by ...