Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Only a few types of molecules can easily sneak through this barrier. These tend to be small, fat-soluble molecules, such as nicotine, oestradiol (used in HRT) or certain painkillers – hence ...

The BBB facilitates the controlled transport of nutrients, metabolites, and essential molecules while blocking unnecessary or harmful compounds. 3 Small, lipid-soluble molecules, oxygen, glucose, and ...

Feb 17, 2025 New lipid nanoparticle platform delivers mRNA to the brain through the blood-brain barrier The findings, demonstrated in mouse models and isolated human brain tissue, could expand ...

BMC Clin Pharmacol. 2010;10:1-27. However, there are some notable exceptions to this general rule where the adipose-blood exchange of several highly lipid soluble molecules seems to be diffusion ...

PTI Updated On Sep 23, 2024 at 04:35 PM IST ...

Serum lipid-soluble micronutrients, such as 25(OH)D and carotenoids, may be protective in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), whereas tocopherols may be ...

The molecules used in the study are more soluble, can transfer and accumulate, are better absorbed, and can move freely between membranes.

‘The [blood–brain] barrier is essential to protect your brain, but when you have a disease it’s kind of a double-edged sword,’ explains Kevin Boyé, a junior group leader at Paris Cardiovascular ...

Oral administration is the preferred route of delivery for therapeutic molecules due to its convenience. However, most New Chemical Entities (NCE) exhibit physico-chemical properties limiting their ...