Their findings, published in npj Regenerative Medicine, reveal similarities and differences in metabolic signaling, lipid mobilization and storage between two regenerating species. In this project ...

This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...

Recent advancements in understanding the molecular basis of the prostaglandin D2 receptor (DP2) have significant implications for developing new anti-inflammatory and anti-allergic therapeutics.

"We pinpointed a novel neurodegenerative microglia phenotype in Alzheimer's disease characterized by a stress-related signaling pathway ... and release toxic lipids. These lipids damage neurons ...

These structures revealed distinct binding modes and provided critical insights into the receptor's activation and signaling bias, highlighting the role of lipid interactions. Using advanced cryo ...