A lipid nanoparticle, delineated in red, fuses with the bilayer membrane of an endosome to allow the RNA strand ... Leal’s solution to make LNPs more fusion-prone is to make them less stable.

Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids. Chemical and Pharmaceutical Bulletin 69 (12); 1141-1159.

To date, lipid nanoparticle (LNP), ... However, increase the length of PEG will also decrease the fusion between LNP and endosome membrane, which is known as “PEG dilemma”.

The lipid nanoparticles that caused an immune response interacted with the cell membrane without disrupting its signaling function. The Whitehead Lab's multi-pronged approach uses both ...

More information: Sue Lyn Yap et al, The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways, Small (2025). DOI: 10.1002/smll.202500903 Provided by RMIT ...

Researchers have developed a nanoparticle technology that can be used to stabilize membrane proteins so that their structure can be studied in a lipid environment. The method makes it possible to ...

First time physicists observed, quantified tiny nanoparticle crossing lipid membrane. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2016 / 11 / 161102144304.htm.

Integral membrane proteins (IMPs), constituting nearly 20–30% of the proteome, carry out diverse functions including cellular signaling, transport, adhesion, and catalysis. Owing to these ...

Lipid-based nanoparticles have emerged as highly useful particles in the pharmaceutical industry. However, their manufacturing involves complex processes and in-process monitoring, such as inline ...

The internal structure of lipid nanoparticles significantly affects cellular uptake, with cubosomes—featuring a 3D cubic architecture—entering cells up to eight times more efficiently than ...