The lipid nanoparticles that caused an immune response interacted with the cell membrane without disrupting its signaling function. The Whitehead Lab's multi-pronged approach uses both ...

A lipid nanoparticle, delineated in red, fuses with the bilayer membrane of an endosome to allow the RNA strand ... Leal’s solution to make LNPs more fusion-prone is to make them less stable.

More information: Sue Lyn Yap et al, The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways, Small (2025). DOI: 10.1002/smll.202500903 Provided by RMIT ...

Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids. Chemical and Pharmaceutical Bulletin 69 (12); 1141-1159.

Researchers have developed a nanoparticle technology that can be used to stabilize membrane proteins so that their structure can be studied in a lipid environment. The method makes it possible to ...

First time physicists observed, quantified tiny nanoparticle crossing lipid membrane. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2016 / 11 / 161102144304.htm.

Integral membrane proteins (IMPs), constituting nearly 20–30% of the proteome, carry out diverse functions including cellular signaling, transport, adhesion, and catalysis. Owing to these ...

Lipid-based nanoparticles have emerged as highly useful particles in the pharmaceutical industry. However, their manufacturing involves complex processes and in-process monitoring, such as inline ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...

The internal structure of lipid nanoparticles significantly affects cellular uptake, with cubosomes—featuring a 3D cubic architecture—entering cells up to eight times more efficiently than ...