A group of University of Ottawa researchers have already shown how scientists can harness gene therapies to deliver ...

Kiran Musunuru, a University of Pennsylvania cardiologist and leading gene-editing researcher, thinks it’s possible. Musunuru cofounded Verve Therapeutics, a company developing a therapy that uses ...

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Nanoemulsions, which are fine dispersions of oil and water phases, are particularly effective for incorporating hydrophobic ...

Tiny fat bubbles carrying gene therapy have successfully repaired DNA in the lungs and liver of animals with alpha-1 antitrypsin deficiency—a promising leap toward treating humans with this rare ...

Borrowing from the anti-inflammatory properties of olive oil, Penn Engineers used a century-old chemical reaction to redesign ...

Surface-engineered LNPs, propelled by clinical successes like patisiran and mRNA vaccines, enable targeted nucleic acid delivery via ligands (antibodies, peptides) and conjugation chemistries (click ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion. The method using targeted ...

A mass spec-based method for analyzing the structure of lipid nanoparticles could yield new insights that improve vaccine and drug delivery.

Our research offers insights into the design of lipid nanoparticles (LNPs), an advanced delivery system for RNA-based therapies, including some of the mRNA vaccines developed during the COVID-19 ...

When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the mRNA ...