Mechanistic studies revealed a dual mode of action, with compound 11 serving as a representative example for its potent bioactivity and exceptional selectivity: it concurrently (1) inhibited lipid ...

By developing drugs that target key lipid metabolism enzymes or modulating adipokine signaling pathways, it is possible to intervene in the development and progression of MM. For instance, inhibiting ...

Although questioned based on inborn errors of metabolism affecting other aspects of ether lipid biosynthesis (54), this body of work indicated that PexRAP can be essential in some aspects of ether ...

The examples discussed above indicate that there is some empirical evidence, although not always fully characterized biochemically, for metabolic pathway drift in plant and algal lipid biosynthesis ...

Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty ...

Microalgae—which are major contributors to global photosynthesis and primary productivity—serve as promising chassis cells in synthetic biology.

Microalgae—which are major contributors to global photosynthesis and primary productivity—serve as promising chassis cells in synthetic biology. In a study published in Plant Communications ...

30 August 2023 Previously unknown pathway for lipid biosynthesis discovered The pathway used by mammalian cells to make triglyceride lipids when supplies of fat molecules are high has long been known.

Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that ...

Muscle degeneration, the most prevalent cause of frailty in hereditary diseases and aging, could be caused by a deficiency in one key enzyme in a lipid biosynthesis pathway. Researchers now ...

Though much of the gut microbiome’s metabolic content (dry weight) comprises lipids, Escherichia coli have been the source of all information about gut bacterial lipid biosynthesis.

The study reveals resilience to membrane perturbations and identifies regulators of lipid homeostasis through rewiring phospholipid biosynthesis.